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NeuroPrint - hybrid printing technology for personalized soft neuromuscular interfaces

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Neural interfaces establish communication between biological systems and electronic devices. Although additive manufacturing has been applied for development of flexible and elastic bioelectronic devices for in vitro applications and external skins, rapid prototyping technologies for neural implants have not been applied. Here, we utilize the capacity of a hybrid printing platform for integration of soft materials and composites into bioelectronic devices well-adapted to various anatomical structures and experimental models, in order to investigate, enable and recover functions of the neuromuscular system. Electromechanical properties of the implants enabled their high biointegration in long-term in vivo experiments, suggesting their potential applications in different fields of translational and clinical neuroscience, including neuroprosthetics and electroceuticals. As a meso-scale fabrication technology, NeuroPrint is well suited to the circuits-level interfacing that is desired for neuroelectronic medicine. Personalized treatment requires on-demand and flexible fabrication technologies that may be utilized in clinical practice, empowered by the development of control electronics and power supply for complete implantable systems. By establishing highly functional and durable interfacing with sensitive neural tissue, NeuroPrint electrodes emerge as a crucial component of such systems.

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The seminar is supported by the Ministry of Science and Higher Education of the Russian Federation by the Agreement № 075-15-2020-933 dated 13.11.2020 on the provision of a grant in the form of subsidies from the federal budget for the implementation of state support for the establishment​ and development of the world-class scientific center «Pavlov​ center «Integrative physiology for medicine, high-tech healthcare,​ and stress-resilience technologies» (NCMU)